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Literature summary extracted from
- Matrix metalloproteinase-26 is associated with estrogen-dependent malignancies and targets alpha1-antitrypsin serpin (2004), Cancer Res., 64, 8657-8665.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.24.B7 | medicine | matrix metalloproteinase-26 is a marker of melanomas and estrogen-dependent carcinomas | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.B7 | expression of proenzyme MMP-26 in Escherichia coli | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.B7 | AG3340 | - |
Homo sapiens |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.B7 | 29000 | - |
proenzyme, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.B7 | alpha1-antitrypsin + H2O | Homo sapiens | MMP-26 by cleaving and inactivating the alpha1-antitrypsin serpin, operates as a unique functional link that regulates a coordinated interplay between Ser and metalloproteinases in estrogen-dependent neoplasm. Involvement of MMP-26 in inflammation and malignant progression of estrogen-dependent tumor | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.B7 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.24.B7 | proteolytic modification | autocatalytically activated in cells and tissues | Homo sapiens |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.24.B7 | recombinantly expressed proenzyme | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.B7 | IGROV-1 cell | - |
Homo sapiens | - |
| 3.4.24.B7 | Ishikawa cell | - |
Homo sapiens | - |
| 3.4.24.B7 | macrophage | matrix metalloproteinase-26 is associated with macrophages and polymorphonuclear leukocytes | Homo sapiens | - |
| 3.4.24.B7 | MCF-7 cell | - |
Homo sapiens | - |
| 3.4.24.B7 | MDA-MB-435 cell | - |
Homo sapiens | - |
| 3.4.24.B7 | OVCAR-3 cell | - |
Homo sapiens | - |
| 3.4.24.B7 | OVCAR-4 cell | - |
Homo sapiens | - |
| 3.4.24.B7 | OVCAR-5 cell | - |
Homo sapiens | - |
| 3.4.24.B7 | OVCAR-8 cell | - |
Homo sapiens | - |
| 3.4.24.B7 | polymorphonuclear leukocyte | matrix metalloproteinase-26 is associated with macrophages and polymorphonuclear leukocytes | Homo sapiens | - |
| 3.4.24.B7 | SKOV-3 cell | - |
Homo sapiens | - |
| 3.4.24.B7 | T-47D cell | - |
Homo sapiens | - |
| 3.4.24.B7 | ZR-75-1 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.B7 | (7-methoxycoumarin)-4-yl-acetyl-Pro-Leu-Gly-Leu-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.B7 | alpha1-antitrypsin + H2O | MMP-26 by cleaving and inactivating the alpha1-antitrypsin serpin, operates as a unique functional link that regulates a coordinated interplay between Ser and metalloproteinases in estrogen-dependent neoplasm. Involvement of MMP-26 in inflammation and malignant progression of estrogen-dependent tumor | Homo sapiens | ? | - |
? | |
| 3.4.24.B7 | alpha1-antitrypsin + H2O | the enzyme is highly efficient in cleaving the the serpin alpha1-antitrypsin at the positions Gln135-/-Leu136, Glu223-/-Val224, Phe376-/-Leu377, and Pro381-/-Met382 | Homo sapiens | ? | - |
? | |
| 3.4.24.B7 | additional information | the enzyme exhibits an unconventional PH81CGVPD Cys switch motif | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.B7 | MMP-26 | - |
Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.24.B7 | 0.0000015 | - |
AG3340 | - |
Homo sapiens | |
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